Dr. Anal Trivedi

Dr. Anal Trivedi |Clyto Access

Faculty, Dharmsinh Desai University, India





Title: Dual effect of Cyclosporin on Gingival enlargement


Cyclosporine A(CsA)-primary tool to prevent the rejection of organ transplants, was introduced in 1972 as a lipophilic cyclic endecapeptide, isolated as an antifungal, from soil samples containing Cylindrocarpon lucidum BOOTH and Tolypocladium inflatum GAMS(fungi imperfecti). Reported side effects of CsA are Nephrotoxicity, Hepatotoxicity, Diabetes, Epilepsy, tremors, lingual fungiform papillae hypertrophy, Plasmacytoma, squamous cell carcinoma of lips, Sinusitis, Hairy leukoplakia, Hypertension, Biliary calculus disease, Neurotoxicity, Hirsutism, Altered bone metabolism, Kaposi’s sarcoma, Conjunctivitis & Gingival Enlagement. Present paper is showing deeper look in cyclosporine induced gingival enlargement by increased collagenous and non collagenous extracellular matrix and  inhibition of degradation of extra cellular matrix. Role of Perlecan, Heparan sulphate, TGF-β, IL-1,IL-6, TIMP-1,2 and Plasminogen activator inhibitor (PAI-1) have been discussed in detailed in this review report.

Key Words: Cyclosporine A, Gingival enlargement, TGF-β , TIMP-1,2, Plasminogen activator inhibitor.


Related Conferences :

Global Forum on Transplantation Research and Technologies