Dr. Chandra Prabha MN

Dr. Chandra Prabha MN |Clyto Access

M.S.Ramaiah Institute of Technology, India


Expertise: Nanomaterials


Dr. Chandra Prabha M N, Professor at Department of Biotechnology, M.S.Ramaiah Institute of Technology, Bangalore, has PhD from Indian Institute of Science. She is a recipient of prestigious 'Career Award for Young Teachers' by AICTE, India. Her areas of interest include synthesis, characterization and application of nanomaterials and nanocomposites. She is working on both chemical and green-mediated synthesis of nanomaterials, application of nanomaterials and polymer-nanomaterial hybrid composites in targeted drug delivery, wound dressing, food packaging etc. She has successfully completed 4 External Funded research projects received from DST, AICTE, VTU and DST-NASI. She has moer than 50 publications in peer reviewed International journals, 5 book chapters and over 50 publications in International conference proceedings.



Title: Chitosan Coated Coumarin Loaded Nickel Ferrite (NiFe2O4) Nanocomposite as a Potential Drug Delivery System


Chemotherapeutic agents used for cancer treatments shows less bioavailability, biocompatibility and poor aqueous solubility with severe side effects. Recently coumarin (1, 2-benzopyrone), a naturally occurring compound present in a wide variety of plants, has attracted great attention because of its extent pharmacological activities. Coumarin has many therapeutic applications including broad spectrum anticancer potential. However, low aqueous solubility and bioavailability limits its application in cancer therapies. The present work aims to explore coumarin functionalized chitosan encapsulated nickel ferrite core as magnetic probe for targeting on tumors as potential drug delivery system. The anticancer drug coumarin was loaded and tagged successfully onto chitosan functionalized nickel ferrite core nanoparticles. The bare nickel ferrite nanoparticles were synthesized by combustion method using glycine as fuel. The synthesized nanoparticles and core shell nanocomposites were characterized by XRD, FTIR spectra and SEM analysis. SEM images of chitosan coated nickel ferrite nanoparticles show octahedral morphology. The particle size range for nickel ferrite nanoparticles was in the order of 70 to 90 nm while, the size of chitosan coated nickel ferrite nanoparticles was 150 nm. These nanocomposites exhibited better anti-inflammatory activity compared to Diclofenac on the basis of hemolysis test. The MTT assay study on cancer MCF-7 cell line has shown that there was a significant increase in anti-cancer activity or toxicity of the coumarin loaded chitosan coated nickel ferrite nanoparticles against MCF-7 breast cancer cell lines suggesting the potential of chitosan coated nickel ferrite nanoparticles as effective drug delivery systems.


Related Conferences :

2nd world summit on Nanotechnology and Nanomedicine Research