Dr. Daisuke Uemura

Dr. Daisuke Uemura |Clyto Access

Kanagawa University, Japan


Expertise: Discovery of extremely bioactive natural products with splendid architectures.


Daisuke Uemura received his Ph.D. from Nagoya University in 1975. In 1982, he began research as a visiting scholar at Harvard University. In 1997, he started working as a Professor at the Nagoya University Graduate School of Science, and in 2009, he was awarded the Medal with Purple Ribbon by the Government of Japan. In 2011, he began work as a Professor in the Department of Chemistry, Faculty of Science, Kanagawa University, and became Director of the Research Institute of Natural Drug-Leads. He was designated Professor Emeritus at Nagoya University in 2008 and a Distinguished Invited Professor at Kanagawa University in 2016. 


Title: Bioactive Metabolites of Okinawan Cyanobacteria


Obesity is a growing health problem in modern society because it is a risk factor for many lifestyle-related diseases, including diabetes and cardiovascular disorders. Thus, studies on anti-obesity are expected to contribute to the prevention and treatment of various diseases. To propose promising drug candidates, we tried to identify the natural product which controls fatty acid metabolism and explication of those mechanisms. Yoshinone A, a ?-pyrone containing-natural product derived from a cyanobacterium Leptolyngbya sp. collected in Ishigaki Island, was first identified as an inhibitor of fat cell differentiation of 3T3-L1 cells1,2. We examined the effect of yoshinone A to adiposities and found that the compound decreased the triglyceride level in the cells. Furthermore, administration of yoshinone A derivative to mice with high fat-diet clearly demonstrated that the compound inhibited weight increase in vivo. These findings suggested that yoshinone A might be a potent drug lead to treat obesity. And then, I will present some new topics.

Dr. Daisuke Uemura, Clyto Access



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