Mr. P.S.S Saikiran

Mr. P.S.S Saikiran  |Clyto Access

Research scholar, JSS university, Ooty India

Poster Presentation

Expertise: Tumor targeted drug delivery, Breast cancer, Chemotherapy


Mr. Pindiprolu Satya Sesha Saikiran obtained his Bachelors in Pharmacy from  Andhra University, Visakhapatnam and his masters from JSS University, Mysuru India. presently he is working as a research scholar in department of pharmacology, college of pharmacy, JSS university, Ooty India.



Title: Nonselective phosphodiesterase inhibition protects against chemotherapy induced peripheral neuropathy in mice and potentiates its apoptotic activity in colorectal adenocarcinoma



Oxaliplatin (OXA) is a third-generation platinum based anticancer agent. OXA is widely used in treatment of advanced colorectal cancer. However, the major limitation of OXA based chemotherapy is peripheral neuropathy which is characterized by severe pain in hands and foot. Peripheral neuropathy also further leads to sensory disturbances and is one of the major reasons for cessation of treatment and hence responsible for decreased efficacy of chemotherapy and increased incidence of tumor relapse. Currently there are no approved medications for prevention of oxaliplatin induced peripheral neuropathy (OIPN). 
In the present study the protective propensity of Pentoxifylline (PTX), a non selective phospho diesterase against OIPN was studied. OXA (1mg/kg body wt) was administered twice weekly to mice, to induce peripheral neuropathy. The PTX was administered daily at doses of 15mg/kg and 30 mg/kg. The total duration of the study is 4 weeks.
OIPN leads to alterations in nerve conduction velocity, oxidative stress and increased the levels of inflammatory markers. Whereas, PTX treatment showed dose dependent prevention of electrophysiological, behavioural and biochemical alterations associated with OIPN. 

Key words: Colorectal cancer; Oxaliplatin; Pentoxifylline; Peripheral neuropathy


Related Conferences :

International Conference on Cancer Care and Cure