Mr. Pubudu N Premarathne

Mr. Pubudu N Premarathne |Clyto Access

University of Peradeniya, Sri Lanka

Organizing Committee Member

Expertise: Physical Chemistry, Pharmaceutical Chemistry, Surface Chemistry, Drug delivery, Liquid crystals, Dispersion systems


Mr. Pubudu N Premarathne, graduated from the University of Peradeniya, Sri Lanka in 2010 and he obtained his Master of Philosophy Degree in Chemistry in 2017 from the University of Peradeniya, Sri Lanka which consists of course work as well as full time research work. He have the knowledge in both Chemistry and Physics and He is interested in Physical Chemistry, Pharmaceutical Chemistry, Surface Chemistry, Drug delivery, Liquid crystals, and Dispersion systems as well as he completed his M.Phil also. Mr. Pubudu has published research papers in index journal; International Journal of Pharmaceutics published by Elsevier Publications, and another in Journal Molecular Crystals and Liquid Crystals which was published by Taylor and Francis. Further, his results were presented at many international and local conferences as well as published abstract in proceedings of URSE - Peradeniya University Research Sessions, proceeding of SLASS- 2013- Sri Lanka Association of Advancement of Science. Again he published his finding in many more international conferences such as First national Nano-science conference – 2012 6th International Conference on Functional Materials & Devices 2017 (ICFMD - 2017) 2017 in Malaysia and 25th International Liquid Crystal Conference 2014 (ILCC) Ireland -2014 etc.



Title: Mathematical modelling of Microemulsion based-novel drug delivery system for Diclofenac sodium with synthesized glycolipid as permeation enhancer


Mathematical models related to the drug release provides detailed description on chemical processes and mass transpiration govern in drug delivery systems as well as the effect of design parameters, such as the device geometry and drug loading, on drug release mechanism with a few experimental studies. In last decades, there were large numbers of researches on controlled release formulations, to enhance the drug effectiveness and decrease the administration periods in treatments with minimal side effect to the patient. This modelling provides important physical parameters such as steady state flux, drug diffusion coefficient regarding the experimental data. It provides detailed description of drug release kinetics as well as this is the ideal tool to understand the comprehension phenomena of releasing process and bring the acceptable and optimized formulation in to market. There are number of theoretical and semi empirical models, which illustrate the overall releasing kinetics of drug. Depending on the qualitative and quantitative changes of the formulation, drug release may be altered. Under thin investigation the releasing process was studied with Zero order model, First-order model, Higuch square root time model, Korsmeyer-Peppas model and Weibull model. In this investigation, optimized ME systems were prepared using Olive oil, water and the non-ionic lipophilic surfactant Sorbitan monooleate (Span 80) by selecting suitable compositions of both W/O (water in oil) and O/W (Oil in Water) emulsion systems from the phase diagram constructed at 70 ºC . Then, Diclofenac sodium (1.00 % w/w) was introduced to the selected W/O and O/W emulsions separately as well as together and in vitro release of both drugs through a pig ear (ear epidermis) fitted to a Franz diffusion cell system was observed with and without glycolipid (hexadecyl-ß-D-glucopyranoside) (0.05% (w/w)) as permeation enhancer. Aqueous solution of DS (1% (w/w)) was used as the control. The optimized ME formulations model drug show higher permeability (Kp) and higher amount of release of 76.35% and 63.52% for W/O and O/W respectively. The kinetics of the release process of DS, can be identified as first order kinetics obeying the Higuchi model of drug release. Release process can be further concluded as a one dimensional diffusion model with Higuchi model and release process was considered to follow diffusion controlled release.


Related Conferences :

2nd world summit on Nanotechnology and Nanomedicine Research