Ms. Naveena Shri S

Ms. Naveena Shri S |Clyto Access

Student, Sri Ramachandra University

Poster Presentation

Expertise:

Biography:

Presentation:

Title: ROLE OF GSTM1 &GSTT1 GENE POLYMORPHISM IN SUSCEPTIBILITY TO ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract:

BACKGROUND:
Acute lymphoblastic leukemia (ALL) characterized by proliferation of immature B or T cells in bone marrow, Lymph nodes, spleen & blood remains the leading cause of cancer related death in children. Many polymorphisms in the genes coding for xenobiotic metabolizing enzymes (XME) has been identified and studies have reported significant association with the gene variation and enzyme activity. The inter -individual variations in the activity of XME could play a role in increasing susceptibility to ALL in pediatric age group. Glutathione Stransferases are enzymes involved in detoxification of several environment mutagen, carcinogens & anticancer drug. This study aims to explore the gene polymorphisms of Glutathione S-transferases (GSTM1 & GSTT1) on Indian children & their relationship with ALL susceptibility.

DISCUSSION:
The glutathione S-transferase mu-1 (GSTM1) and glutathione S-transferase theta-1 (GSTT1) are phase II enzymes that have the ability to detoxify numerous electrophilic compounds
including the activated carcinogens. Both GSTM1 and GSTT1 exhibit genetic polymorphism in populations with a large percentage of individuals displaying a homozygous deletion of the structural genes. Studies have reported contradictory results for associations between GSTM1 and GSTT1 and cancer predisposition.
Conclusion:
Children with acute lymphoblastic leukemia show higher percentage of deletion of GSTT1, when compare to the control group of normal children

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Related Conferences :

International Conference on Cancer Care and Cure