Ms. Santilna

Ms. Santilna  |Clyto Access

Lecturer, JSS College of Pharmacy, India.

Poster Presentation

Expertise: Pharmacology, Cancer Cells

Biography: Ms. Santilna has completed her Bachelor of Pharmacy and Masters of Pharmacy (Pharmacology) from JSS College of Pharmacy Mysore, India. Later she started working as a lecturer in Karuna College of Pharmacy,Palakkad, Kerala. presently she is working as a lecturer in JSS College of Pharmacy, Udhagamandalam, Tamil Nadu, India.,


Title: Selective killing of cancer cells by fruit extract ofCucumistrigonus: Componentsand itsin vitro cytotoxicityand in vivostudies


The present study was carried out to determine the antitumor activity of Cucumistrigonusfruitsextractsagainstcancer cell lines namely HeLa, HEp-2, A-549, MCF-7, MDA-MB 231, HT-29 and C-6 and two normal (L-929, Vero) cell lines. The Cucumistrigonus fruits were extracted using n-hexane, toluene, chloroform, ethylacetate, hydroalcoholic and aqueous solvents and it’sin vitro cytotoxicity studies have been carried out. Amongthe extracts, toluene and chloroform extracts showed a potential activity (CTC50 < 1µg/ml).TLC profiling of toluene extract namely fraction F23 and F24 showed highest cancer cell killing activity (CTC50 <0.1 µg/ml). The active chloroform extract obtained from Cucumistrigonus was found to reduce the tumor and associated symptoms in DLA induced ascites tumor bearing mouse.This study indicates that the tolueneand chloroform extracts of Cucumistrigonus possesses significant antitumor activityin vitro which may be due to high cytotoxicity toward the cancer cell line. Our studies encourage the development of novel, efficient and less toxic plant derived molecular for the cancer chemotherapy.

 Keywords: Cucumistrigonus, cytotoxicity, human cancer cell lines


Related Conferences :

International Conference on Cancer Care and Cure